【摘要】 目的评价盐酸戊乙奎醚(长托宁)对慢性阻塞性肺病(COPD)的支气管扩张作用。方法将92例COPD患者随机分为盐酸戊乙奎醚组31例,异丙托溴铵组34例,对照组27例,两个药物组吸入相应的药物,3组均吸入高浓度氧。测定所有患者用药前后第1秒用力呼气量(FEV1)变化。结果盐酸戊乙奎醚组和异丙托溴铵组FEV1较用药前均有显著增加(P<0.05)。以FEV1改善率>15%视为有效,此两组的有效率均高于80%,二者比较无显著差异(P>0.05)。对照组有效率低,与两个药物组比较差异显著(P<0.05)。结论抗胆碱能药物通过降低肺动脉压力而明显改善COPD患者通气功能。更多还原

【Abstract】 Objective To evaluate the efficiency of penehyclidine hydrochloride in patients with chronic obstructive pulmonary disease(COPD).Methods Ninety-two patients with COPD were randomly divided into three group:31 patientsin penehyclidine hydrochloride,34 ones in atrovent and 27 ones in control group.The patients in two drug groups inhaled corresponding drugs,all patients in three groups inhaled high-concentration oxygen.The forced expiratory volume in one second(FEV1) was measured before and after inhalation.Results FEV1 in two kinds of drug group were both improved after inhalation(P<0.05).The efficiency of the two drugs were both higher than 80%,taking the improvement rate>15% as effectiveness,but there was no significant difference between both(P>0.05).The efficiency of control group was lower,being different from that of the drug groups(P<0.05).Conclusions Penehyclidine hydrochloride can obviously improve the lung function of patients with COPD by reducing the pulmonary arterial pressure.更多还原