【摘要】 目的探讨糖尿病(DM)模型大鼠坐骨神经传导速度的动态变化。方法采用大鼠腹腔内注射链脲佐菌素(STZ)溶液,制备DM大鼠模型。将80只Wistar大鼠随机分为对照组(NC组),成模即刻(0w)组、成模后2、4、8、12w组。应用Medtronic公司的CantataTM肌电图机检测大鼠下肢坐骨神经的感觉(SNCV)和运动神经传导速度(MNCV)。结果造模前及成模4w内DM组和NC组大鼠SNCV和MNCV无显著差异;自成模后4w,DM组大鼠SNCV和MNCV开始减慢,并随着病程延长而逐渐进展,在成模后4、8、12w时SNCV和MNCV较NC组分别降低10.91%和10.42%,14.81%和14.89%,16.36%和17.39%,与NC组比较均有极显著差异(P<0.01)。结论DM大鼠早期(4w时)周围神经即可出现明显的功能障碍,且其损伤程度随病程的延长而加重。更多还原

【Abstract】 Objective To observe the changes of sciatic nerve sensory and motor conduction velocity of diabetes mellitus(DM) rats at different time points.Methods DM models were established by streptozocin(STZ)(60 mg/kg) intraperitoneal injection.80 Wistar rats were randomly divided into control,DM 0,2,4,8,12 w groups.Sciatic nerve motor nerve conduction velocities(MNCV) and sensory nerve conduction velocities(SNCV) were measured by Medtronic Keypoint-4 Workstation electromyography in different time points.Results Compared with control group,DM group rats showed no significant differences in SNCV and MNCV before and 4 w after STZ injection.Since 4 w after STZ injection,DM rats began to show the slowness of SNCV and MNCV.The slowness progressed with the extension of DM course.Compared with those of control group,SNCV and MNCV of DM 4,8,12 w groups were decreased 10.91% and 10.42%,14.81% and 14.89%,16.36% and 7.39%,respectively(P<0.01).Conclusions DM rats appear obvious peripheral nerve function disturbances in the early period(4 w),and the damages are aggravated with the extension of DM course.更多还原