【摘要】 目的应用动态血糖监测系统(CGMS)评估果糖及木糖醇注射液对老年2型糖尿病血糖波动的影响,为老年2型糖尿病患者的补液治疗提供选择依据。方法选择稳定期老年2型糖尿病患者20例,采用自身对照方法,随机在第1,2,3天9:00～11:00分别匀速静脉滴注0.9%生理盐水200ml、5%果糖注射液200ml或5%木糖醇注射液200ml。同时用CGMS监测血糖的动态变化,比较9:00～12:00血糖波动情况。结果生理盐水组、果糖组、木糖醇组9:00～12:00(180min)内血糖最高值〔(10.63±2.42)vs(9.87±1.96)vs(10.18±1.44)mmol/L〕、血糖最低值〔(5.34±1.72)vs(5.95±1.68)vs(5.63±1.45)mmol/L〕、血糖平均值〔(7.78±1.85)vs(7.73±1.42)vs(7.19±0.87)mmol/L〕、血糖波动最大幅度〔(5.29±2.24)vs(3.93±2.53)vs(4.56±2.15)mmol/L〕、血糖标准差〔(1.67±0.61)vs(1.49±0.65)vs(1.62±0.61)mmol/L〕及血糖曲线下面积(AUC)〔(1377.40±295.51)vs(1391.75±258.57)vs(1425.84±157.38)mmol.min-1.L-1〕。三组间血糖最高值、最低值、平均值、血糖波动最大幅度、血糖标准差及血糖AUC均无显著区别(P>0.05)。结论果糖注射液及木糖醇注射液对老年2型糖尿病患者的血糖波动无明显影响,可作为其补液治疗的安全选择。更多还原

【Abstract】 Objective To investigate the effect of fructose and xylitol injection on blood glucose fluctuation of elderly type 2 diabetes(T2DM)patients by continuous glucose monitoring system(CGMS)and provide them with evidence for the selection of rehydration treatment.MethodsBy self-controlled methods,20 elderly T2DM patients in stable phase were selected and were injected with 0.9% normal saline 200 ml,5% fructose injection 200 ml or 5% xylitol 200 ml on 9:00～11:00 from the 1st day to the third day randomly at constant speed.The blood glucose dynamic variation was monitored by CGMS,and the fluctuation of blood glucose from 9:00 to 12:00 was compared.ResultsThe maximum(Max),minimum(Min)and mean(Mean)of blood glucose,Max amplitude of blood glucose fluctuation(MAGE),standard deviation of blood glucose(SD)and area under curve(AUC)of patients from normal salines,fructose and xylitol groups on 9:00～12:00 were as the followings:Max〔(10.63±2.42)vs(9.87±1.96)vs(10.18±1.44)mmol/L〕,Min〔(5.34±1.72)vs(5.95±1.68)vs(5.63±1.45)mmol/L〕,mean〔(7.78±1.85)vs(7.73±1.42)vs(7.19±0.87)mmol/L〕,MAGE〔(5.29±2.24)vs(3.93±2.53)vs(4.56±2.15)mmol/L〕,SD〔(1.67±0.61)vs(1.49±0.65)vs(1.62±0.61)〕,AUC〔(1 377.40±295.51)vs(1 391.75±258.57)vs(1 425.84±157.38)mmol·min-1·L-1〕correspondingly.No significant differences of Max,Min,Mean,MAGE,SD or AUC were found among patients from three groups(P>0.05).In addition,no adverse effects were reported.ConclusionsFructose and xylitol injections have little effect on blood fluctuation of T2DM patients and can be chosen for rehydration safely.更多还原