【摘要】 目的探讨直肠癌局限性肝转移的手术及术后经门静脉途径灌注化疗的安全性和有效性。方法对40例直肠癌局限性肝转移患者行手术治疗,其中同时性肝转移18例行同时性手术。术后随机分组行前瞻性对照研究,A组22例行门静脉途径灌注化疗,B组18例行周围静脉化疗,随访观察治疗效果。结果所有患者均安全度过围手术期,无严重并发症,A组术后生存率和复发率均优于B组,差异有统计学意义(P<0.05)。结论直肠癌局限性肝转移行手术治疗效果好;直肠癌同时性肝转移者采用同时性手术是安全可行的;术后经门静脉途径化疗可进一步提高疗效。更多还原

【Abstract】 Objective To explore the safety and effective of surgical resection and postoperative chemotherapy by portal vein incubation for rectal cancer with limited liver metastasis.Methods 40 patients of rectal cancer with limited liver melaslasis were treated by surgical resection and,18 patients in them with synchronous liver melaslasis received hepatectomy and primary rectal resection simultaneously.After operation,all of the 40 patients were randomly divided into two groups in order to study the postoperative chemotherapical approach, prospectively.A group(22 patients) received postoperative chemotherapy by portal vein incubation and B(18 patients) group by peripheral vein.Results All patients passed the dangerous period and no serious complications occurred.The 3-year recurrent rates and 5-year survival rates in group A were better than those of in group B(P<0.05).Conclusions Rectal cancer with limited liver metastasis can be treated by surgical resection, hepateclomy combined with primary rectal resection simultaneously for patients with synchronous liver metastasis is safe,feasible and effective.The postoperative chemotherapy by portal vein incubation is better than that by peripheral vein due to the better effection.更多还原