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热休克蛋白(HSP70)在胆囊癌中的表达及其意义
Expression of HSP70 in carcinoma of gallbladder and significance
【摘要】 目的探讨热休克蛋白(HSP70)与胆囊癌的发生及发展的关系。方法用免疫组化sP法检测45例胆囊癌中热休克蛋白的表达情况,并与4l例慢性胆囊炎标本做对照。结果热休克蛋白(HSP70)在胆囊癌中普遍呈现高表达,而在慢性胆囊炎组织中不同程度地呈现弱表达;HSPT0在胆囊癌组织中的表达明显高于慢性胆囊炎组(Jp<O.01),且强阳性表达高于后者(JP<O.01)。结论胆囊癌是HSP70高表达肿瘤,HSP70在原发性胆囊癌中普遍高表达,提示与胆囊癌的发生发展有关。
【Abstract】 Objective To examine the relationship between HSP70 and genesis and development of carcinoma of gallbladder.Methods Expression of HSP70 was detected by immunohistochemistry in 45 cases of carcinoma of gallbladder and 41 chronic cholecystitis specimen.Results Expression of HSP70 is higher in carcinoma of gallbladder comparing with chronic cholecystitis tissues(P < 0.O1)and positive expression of HSP70 is also higher than the latter(P < 0.01).Conclusions Expression of HSP70 is higher in carcinoma of gallbladder when compared with chronic cholecystitis tissues.It suggests that expression of HSP70 might play an important role in the genesis and development of carcinoma of gallbladder.
- 【文献出处】 中国肿瘤外科杂志 ,Chinese Journal of Surgical Oncology , 编辑部邮箱 ,2009年03期
- 【分类号】R735.8
- 【被引频次】2
- 【下载频次】15