【摘要】 目的具体评估电视胸腔镜肺癌根治术(VATS)与传统标准后外侧切口开胸手术(SPT)对肺癌患者机体的创伤程度。方法 120例患者随机划入VATS组和SPT组各60例,术后病理证实的肺癌患者为98例。对每例患者术前1天、术后第1、3、5、7天清晨、空腹抽取静脉血,用ELISA方法测量血清中IL-6、IL-10、TNFα的浓度。应用SPSS 13.0统计软件比较术前、术后两组患者炎性因子的变化。结果两组患者术后炎性因子均较术前有明显变化(P<0.05)。IL-6、IL-10的浓度在术后第1、3、5、7天VATS组浓度变化较SPT组要低(P<0.05)。TNFα浓度变化在第1、3、5天变化VATS组较SPT组较低。结论 VATS肺癌根治术对肺癌患者机体创伤相对于传统标准后外侧切口开胸术要小。更多还原

【Abstract】 Objective This study aimed to access the changes of pro-inflammatory cytokines in lung cancer surgery and compare the difference of surgical injury between VATS and standard posterolateral thoracotomy(SPT).Methods 98 patients who underwent lobectomy were randomly divided into VATS group(n =30) and SPT group(n = 30).The blood sample was collected in the morning on dl,d3,d5 and d7 postoperatively. Plasma levels of IL-6,IL-10 and tumor necrosis factor(TNF) were determined by enzyme linked immunosorbent assay(ELISA).The statistical difference before and after surgery was analyzed by SPSS software.Results There were significant difference in plasma levels of pro-inflammatory factors between post-and pre-operation(P< 0.05).The difference of IL-6 and TNF was not significant between VATS and SPT group(P > 0.05). The VATS group showed lower level of IL-6 on dl,d3,and d7 postoperatively compared with SPT group.Conclusion VATS causes less surgical injury than SPT to the lung cancer patients.更多还原