【摘要】 目的探讨P-糖蛋白(P-gp)和谷胱甘肽转移酶(GST-π)在新辅助化疗乳腺癌组织的表达及临床意义。方法采用免疫组织化学方法检测100例乳癌患者新辅助化疗前后肿瘤组织中P-gp及GST-π的表达,并与疗效作相关性分析。结果新辅助化疗总有效率79%,P-gp、GST-π阳性者化疗有效率分别为69.04%和77.08%,阴性者分别为86.20%(P<0.05)和80.76%(P>0.05)。P-gp在化疗前后的阳性表达率分别为41.75%和64.83%,差异有统计学意义(P<0.05);GST-π在化疗前后阳性表达率分别为49.45%和54.94%,差异无统计学意义(P>0.05)。结论新辅助化疗后P-gp表达显著升高,P-gp对乳腺癌新辅助化疗疗效有一定预测价值。更多还原

【Abstract】 Objective To explore the expression of P-gp and GST-π in breast cancer tissue receiving neoadjuvant chemotherapy and explore its clinical significance.Methods Expressions of P-gp;GST-π in 100 breast cancer patients before and after neoadjuvant chemotherapy were measured by immunohistochemistry Envision method.The relationship between P-gp,GST-π and the effect of neoadjuvant chemotherapy was analyzed by chi-square test.Results The overall response rate to neoadjuvant chemotherapy was 79%.In patients with P-gp,GST-π positive expression,the response rate to chemotherapy were 69.04%,and 77.08%,and in patients with P-gp,GST-π negative expression,the response rate to chemotherapy were 86.20%(P<0.05) and 80.76%(P>0.05).The positive expression of P-gp before and after chemotherapy were 41.75% and 64.83%,respectively,and their difference was statistically significant(P<0.05).The positive expression of GST-π before and after chemotherapy were 49.45% and 54.94%,respectively,and no difference was found between them(P>0.05).Conclusion The expression of P-gp increased significantly after neoadjuvant chemotherapy.It suggested that P-gp could be used to predict the therapeutic efficacy of neoadjuvant chemotherapy.更多还原