【摘要】 目的:探讨精神分裂症患者全脑灰质体积变化及其特点。方法:对85例精神分裂症患者和85例健康对照进行脑结构磁共振成像,以最近更新的基于体素的形态测量法检测两组的脑灰质体积差异。结果:精神分裂症患者存在脑灰质体积下降,主要位于双侧颞上回、岛叶和额下回,左侧海马和右侧颞下回。结论:额叶、颞叶和边缘脑区的异常可能是精神分裂症的关键的病理基础。更多还原

【Abstract】 Objective: To characterize the gray matter volume alteration in schizophrenia. Methods: Anatomical images were obtained from 85 schizophrenic patients and 85 healthy controls. Difference of gray matter volume between the two groups was examined by the latest updated voxel-based morphometric method. Results: Schizophrenic patients were associated with reduction of gray matter volume in bilateral superior temporal gyrus, insula and inferior frontal gyrus, left hippocampus and right inferior temporal gyrus. Conclusion: The frontal, temporal and limbic gray matter volume reduction may be the key substrate to schizophrenia.更多还原