【摘要】 目的观察莫诺苷对大脑中动脉阻塞法(MACO)致脑缺血再灌注模型大鼠脑梗死体积的影响。方法用线栓法制备局灶性脑缺血再灌注大鼠模型,缺血30min,再灌注7d。采用2,3,5-氯化三苯基四氮唑(TTC)染色,检测大鼠的脑梗死体积。结果与假手术组相比,模型组及给药组出现明显梗死灶;与模型组相比,莫诺苷(90mg/kg,270mg/kg)脑梗死体积显著减少,维生素E(35mg/kg)组脑梗死体积未出现明显改变。结论莫诺苷可减少局灶性脑缺血再灌注大鼠脑梗死体积,对脑缺血再灌注损伤有保护作用。更多还原

【Abstract】 Objective To observe the effect of morroniside on cerebral infarction volume in focal cerebral ischemia-reperfusion rat model.Methods The animal model was induced by occlusion of middle cerebral artery with suture embolus,ischemia for 30 minutes,and reperfusion for 7 days.The infarction volume was measured by 2,3,5-triphenyltetrazolium chloride(TTC) staining technique.Results Compared with sham operation group,the cerebral infarction volume ratios increased obviously in model group and in the drug-treated(90 mg/kg,270 mg/kg)groups.Compared with model group,the cerebral infarction volume ratios decreased obviously in the morroniside-treated(90 mg/kg,270 mg/kg)group,while the cerebral infarction volume ratios in vitamin E-treated(35 mg/kg)group didn’t change.Conclusion Morroniside may decrease the cerebral infarction volume after cerebral ischemia-reperfusion.It possesses protective effect against cerebral ischemia-reperfusion injury.更多还原