【摘要】 目的:观察新辅助化疗对乳腺癌外周血微转移因子的影响。方法:以48例具备新辅助化疗条件的乳腺癌患者为研究对象,采用RT-PCR技术,联合检测外周血中CK-19 mRNA、VEGF mRNA和hMAM mRNA的表达,观察新辅助化疗前后血微转移因子变化。结果:本组乳腺癌微转移因子阳性率在病理分级中差异无显著性意义(P>0.05);在分期中,分期越高阳性率越高(P<0.05);化疗方案可影响微转移因子阳性率的变化(P<0.01)。结论:通过检测乳腺癌患者外周血中微转移因子,有可能成为判断乳腺癌预后和指导治疗的指标。更多还原

【Abstract】 Objective:To explore the influence of neoadjuvant chemotherapy on peripheral micrometastasis factors in breast cancer.Methods:CK-19mRNA,VEGFmRNA and hMAMmRNA in peripheral blood of 48 breast cancer patients were detected using RT-PCR before and after neoadjuvant chemotherapy.Results:No significant difference in the breast micrometastasis factors was noted in different pathological stages(P>0.05);the positive rate of micrometastasis factors was higher in upper clinical stages(P<0.05).Chemotherapy had positive effect on micrometastasis factors(P<0.01).Conclusion:The factors of peripheral micrometastasis could be tested for breast cancer patients,guiding prognosis and treatment.更多还原