【摘要】 目的:研究维吾尔族及哈萨克族人肿瘤坏死因子受体2(tumor necrosis factor receptor2,TNFR2)第6外显子196位点基因多态性与冠心病的相关性。方法:采用病例对照研究的方法,用ShineRoar探针技术检测117名冠心病患者(其中维吾尔族人89名,哈萨克族人28名)以及106名健康体检者(其中维吾尔族人51名,哈萨克族人55名)的TNFR2第6外显子196位点的基因型。结果:维吾尔族冠心病患者与一般人群TNFR2第6外显子196位点等位基因及基因型频率的差异没有统计学意义;哈萨克族TNFR2第6外显子196位点G等位基因携带者发生冠心病的风险明显高于T等位基因携带者(OR=3.560,95%CI:1.157~8.139,χ2=9.73,P=0.002);TG或GG基因型携带者发生冠心病的风险明显高于TT基因型携带者。两分类Logistic回归分析结果显示,在控制性别和年龄不变的情况下,哈萨克族TNFR2第6外显子G等位基因与冠心病的发生明显相关(OR=4.100,95%CI:1.315~12.780,χ2=5.916,P=0.015)。结论:哈萨克族TNFR2第6外显子G等位基因是发生冠心病的主要危险因素之一。更多还原

【Abstract】 Objective: To study the association of biallelic polymorphism at position 196 in exon 6 of tumor necrosis factor receptor 2(TNFR2) gene and with coronary artery disease(CAD).Methods: A prospective case control study was designed in this investigation.One hundred and seventeen patients(89 were Uighur and 28 from Kazakh) with CAD were compared to with 106 health examination volunteers(51 were Uighur and 55 from Kazakh).Genotyping was performed by ShineRoar probes analysis. Results: There was no significant difference in genotype frequencies for TNFR2 polymorphism between Uighur patients with CAD and Uighur health examination volunteers.Kazakh people with G allele of TNFR2 gene had more risks of development of CAD(OR=3.560,95% CI: 1.157~8.139,χ2=9.73,P=0.002) than those with T allele.Further analysis with adjustment for sex and age demonstrated that G allele at position 196 in exon 6 of TNFR2 gene was significantly associated with CAD(OR=4.100,95% CI: 1.315~12.780,χ2=5.916,P=0.015). Conclusion: Tumor necrosis factor receptor 2 gene polymorphism was independent risk factor of development of CAD among Hazakh people.更多还原