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过敏性疾病患者血清Th1/Th2细胞因子和趋化因子测定及其意义

Determination of Th1/Th2 cytokines and chemokines in patients with allergic diseases and its significance

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【作者】 韩睿林爱华朱可建程浩吴善东

【Author】 HAN Rui1,LIN Ai-hua1,ZHU Ke-jian1,CHENG Hao1,WU Shan-dong2(1.Department of Dermatology,Sir Run Run Shaw Hospital,College of Medicine,Zhejiang University,Hangzhou 310016,China;2.Allergy Research Center,Zhejiang University,Hangzhou 310016,China)

【机构】 浙江大学医学院附属邵逸夫医院皮肤科浙江大学过敏研究中心

【摘要】 目的:检测过敏性疾病患者血清Th1细胞因子IFN-γ和Th2细胞因子IL-4、IL-5、IL-13以及趋化因子Eotaxin、RANTES、LTB4的水平,探讨其临床意义。方法:过敏性疾病患者64例,正常对照21例。采用双抗体夹心酶联免疫吸附实验(ELISA)检测血清IL-4、IL-5、IL-13、IFN-γ、LTB4、RANTES和Eotaxin水平。结果:1过敏性疾病患者血清IL-4、IL-5、IL-13和Eotaxin、LTB4水平较对照组明显增高,差异有统计学意义(P<0.05)。2IFN-γ和RANTES在过敏性疾病患者血清中的水平低于对照组,但无统计学差异(P>0.05)。3IL-4、IL-5、IL-13和LTB4彼此之间呈显著正相关(P<0.01)。4Eotaxin、RANTES和IFN-γ彼此之间呈显著正相关(P<0.05)。5LTB4和Eotaxin之间呈显著正相关(P<0.01)。结论:过敏性疾病的发生存在多种细胞因子和趋化因子复杂的相互作用。

【Abstract】 Objective: To determine Th1/Th2 cytokines and chemokines in patients with allergic diseases and its clinic significance.Methods: Serum levels of IFN-γ,IL-4,IL-5,IL-13,Eotaxin,RANTES and LTB4 were determined from peripheral blood of 64 allergic patients and 21 healthy controls with ELISA.Results: IL-4,IL-5,IL13 and Eotaxin,LTB4 were increased significantly in serum of allergic patients compared with those of controls(P<0.05).There were no significant differences in serum levels of IFN-γ and RANTES between patients and controls(P>0.05).Serum levels of IL-4,IL-5,IL-13 and LTB4 were correlated with each other(P<0.01).Eotaxin,RANTES and IFN-γ levels were also significantly correlated with each other(P<0.05).LTB4 was correlated with Eotaxin as well(P<0.01).Conclusion: A wide range of cytokines and chemokines is involved in allergic diseases,which may play their roles in a complex interactive manner.

【基金】 2008年第一批获出国留学人员在杭创业资助基金(杭人专【2008】188号)
  • 【文献出处】 浙江大学学报(医学版) ,Journal of Zhejiang University(Medical Sciences) , 编辑部邮箱 ,2009年04期
  • 【分类号】R593.1
  • 【被引频次】24
  • 【下载频次】294
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