【摘要】 转移是恶性肿瘤死亡的主要原因,TM4SF(跨膜四超蛋白家族)与整合素结合形成跨膜复合体,通过调节细胞的黏附和移动,对肿瘤的侵袭及转移过程起着重要作用。文中对近年来关于TM4SF的结构、与整合素结合的形式和特点,以及与肿瘤转移的有关机制进行了综述。更多还原

【Abstract】 Distant metastasis is the main cause of cancer death. Tetraspanins (transmembrane 4 superfamily,TM4SF) is capable of forming transmembrane complexes with integrin family participating in cell adhesion,migration and tumor metastasis. This review elucidates the structure of tetraspanins and its function in regulating metastasis as form of multimolecular transmembrane complexes with integrin.更多还原