【摘要】 临床上许多骨不连或者延迟愈合往往出现在骨愈合的早期,等到发现已为时已晚。X线片目测骨盐含量变化达成25%才能分辨,因而无法观察极有临床意义的早期变化。本文介绍了骨折愈合理论和骨不连的定义,多细胞基本单位(BMU)和OPG-RANKL-RANK系统在骨重建中的作用;在超声检测、振动响应分析、机械阻抗分析、骨髓腔造影技术、高分辨率CT等方面对骨的研究以及早期诊断骨折不愈合已有相关的报道,但缺乏分子水平上的早期诊断方法研究。更多还原

【Abstract】 Many clinical bone nonunion or delayed union often appear in the early stage of bone healing,but they have been always found too lately.Before X-ray films of visual changes indicates salt content inbones reaching 25%,the very early changes of clinical significance can not be observed.This paper introduces the theory of fracture healing and the definition of bone nonunion and the significance of the basic multicellular unit (BMU) and the OPG-RANKL-RANK system in bone reconstruction.Many technologies such as ultrasonic testing,vibration analysis,mechanical impedance analysis,the bone marrow cavity imaging technologiy,high-resolution CT etc,have been reported in study on the bone,as well as early diagnosis of fracture nonunion.However,the molecular level of early diagnosis is deficiency.更多还原