【摘要】 目的:探讨脑挫伤灶周围区HSP70表达及川芎嗪和尼莫地平对其干预作用。方法:采用Feenys自由落体法复制大鼠脑挫伤动物模型。川芎嗪和尼莫地平治疗24h、48h、72h取脑切片,用S-P免疫组化方法检测HSP70阳性细胞。结果:模型组HSP70在24h、48h、72h均增多,治疗组HSP70表达更高于模型组(P<0.05),川芎嗪和尼莫地平联合治疗组HSP-70阳性细胞最多。结论:川芎嗪和尼莫地平均能上调脑挫伤灶周区HSP70表达,并保护神经元。更多还原

【Abstract】 Objective:To identify the expression of HSP70 in cerebral injury focus perienchyma and affection of ligustrazine and nimodipine.Methods:The cerebral injury models of rat were made by Feeney’s falling boday injury and used for ligustrazine and nimodipine treatment.After 24h,48h and 72h cerebral were taken and sectioned,in which HSP70 cells were examined by SP immunohistochemistry.Results:At 24h,48h and 72h,the HSP70 protective cells were increased in model group.In the treated group it was significant increased than that of model group(P<0.05).The HSP70 protective cells were the most in the group of ligustrazine combined nimodipine treatment.Conclusion:The ligustrazine and nimodipine could protect the neurons from cerebral injury by decreasing the expression of the HSP70 in injury parenchyma.更多还原