【摘要】 目的:探讨老年肺癌MGMT、LRP、HIF-1α表达与临床预后之间的关系。方法:应用组织芯片技术和免疫组织化学方法检测34例老年肺癌MGMT、LRP、HIF-1α的表达,并与临床预后资料进行相关性分析。结果:MGMT、LRP、HIF-1α在老年肺癌的阳性表达率分别为47%(16/34)、58%(19/34)、64%(22/34);MG-MT阳性表达与组织学类型、TNM分期密切相关(P<0.05),与肿瘤体积、淋巴结转移无关(P>0.05);LRP阳性表达与TNM分期、淋巴结转移密切相关,与组织学类型、肿瘤体积无关(P>0.05);HIF-1α阳性表达与组织学类型、肿瘤体积密切相关,与TNM分期、淋巴结转移无关(P>0.05)。经多因素Cox比例风险模型分析显示:TNM分期、肿瘤组织类型及MGMT、HIF-1α阳性表达与肺癌患者术后生存率有关(P<0.05)。结论:TNM分期、肿瘤组织类型及MGMT、HIF-1α可作为老年肺癌的独立预后指标。更多还原

【Abstract】 Objective:To investigate the relationship between MGMT、LRP、HIF-1α’s expression and prognosis in old-aged lung carcinoma.Methods:The expressions of proteins MGMT、LRP、HIF-1α were detected by immunohistochemistry method and tissue microarray technology in 34 cases of old-aged lung carcinoma and the relationship between the expressions of MGMT、LRP、HIF-1α and clinical prognosis was analysed.Results:The expression ratios of MGMT、LRP、HIF-1α were 47%(16/34)、58%(19/34)、64%(22/34)respectively;The expression of MGMT was associated with histological grading、TNM staging(P<0.05),but not associated with tumor volume and lymph node metastasis(P>0.05);the expression of LRP was associated with TNM staging and lymph node metastasis(P<0.05),but not associated with tumor volume and histological grading(P>0.05);the expression of HIF-1αwas associated with tumor volume、histological grading(P<0.05);but not associated with TNM staging and lymph node metastasis(P>0.05);In the multivariate Cox analysis,survival rate was correlated with TNM staging,histological grading,MGMT and HIF-1α(P<0.05).Conclusion:TNM staging,histological grading,the expression of MGMT、HIF-1αcan be regarded as independent index of old-aged lung carcinoma respectively.更多还原