【摘要】 目的了解中缅边境西段恶性疟原虫对蒿甲醚等7种抗疟药的敏感性,以指导合理用药。方法2003年采用WHO推荐的体外微量法测定恶性疟原虫对蒿甲醚、氯喹、哌喹、萘酚喹、咯萘啶、本芴醇和青蒿琥酯7种抗疟药的敏感性。结果对恶性疟原虫的ID50和CI MC,蒿甲醚为299.2和1 253.2 nmol/L;氯喹为123.0和325.9 nmol/L,抗性率83.33%;哌喹为167.5和628.1 nmol/L,抗性率91.67%;萘酚喹为57.5和176.6 nmol/L;本芴醇为89.5和472.1nmol/L;咯萘啶为40.1和137.1 nmol/L,抗性率31.58%;青蒿琥酯为14.4和30.6 nmol/L。结论当地恶性疟原虫对氯喹、哌喹仍具抗性,但抗性程度呈下降趋势;对青蒿素类药物及咯萘啶基本敏感,但敏感性呈下降趋势;对新药萘酚喹、本芴醇敏感。更多还原

【Abstract】 Objective To ascertain the susceptibility of Plasmodium falciparum to seven antimalarials,including artemether,in the Western part of the Sino-Myanmar border area and to guide rational antimalarial use.Methods An in vitro micro-test recommended by the WHO was used to assay the susceptibility of P.falciparum to artemether,chloroquine,piperaquine,pyronaridine,naphthoquione,benflumetol,and artesunate in 2003.Results With respect to P.falciparum,the ID50 and CIMC(mean concentration completely inhibiting schizont formation) of artemether were 299.2 and 1 253.2 nmol/L and those of chloroquine were 123.0 and 325.9 nmol/L,with a resistance rate of 83.33%.The ID50 and CIMC of piperaquine were 167.5 and 628.1 nmol/L,and the resistance rate was 91.67%.The ID50 and CIMC of pyronaridine were 40.1 and 137.1 nmol/L,and the resistance rate was 31.58%.The ID50 and CIMC of benflumetol were 34.1 and 494.0 nmol/L.The ID50 and CIMC of naphthoquione m were 57.5 and 176.6 nmol/L.The ID50 and CIMC of artesunate were 14.4 and 30.6 nmol/L.Conclusion Local P.falciparum still has resistance to chloroquine and piperaquine,but its susceptibility has tended to decrease.It is susceptible to malaridine and artemisinin-based drugs,but its susceptibility has tended to decrease.P.falciparum is susceptible to the new antimalarials naphthoquione and benflumetol.更多还原