【摘要】 目的评价三苯双脒肠溶片治疗肠道线虫感染者的安全性和疗效。方法在海南省屯昌县进行开放临床试验,受治者用改良加藤法(Kato-Katz)粪检确诊为钩虫、蛔虫感染,钩虫与蛔虫混合感染或合并鞭虫感染等,共收治785例。4~14岁儿童感染者顿服三苯双脒200 mg;>14岁蛔虫感染者顿服三苯双脒300 mg,钩虫和蛔虫混合感染及钩虫或蛔虫合并其他肠道蠕虫感染顿服三苯双脒400 mg,观察不良反应,并于治疗后3~4周用相同方法粪检,评价治疗效果。结果总体钩虫感染治愈率及有效率分别为86.57%(606/700)和98.86%(692/700);蛔虫感染治愈率及有效率分别为82.84%(111/134)和98.51%(132/134);儿童钩虫感染治愈率及有效率分别为86.16%(249/289)和98.62%(285/289);儿童蛔虫感染治愈率及有效率分别为81.75%(103/126)和99.21%(125/126)。三苯双脒的不良反应轻微且短暂,不良反应出现率为2.42%(19/785),主要表现为头晕、恶心和呕吐,对血、尿常规、肝肾功能和心电图无明显影响,儿童未见不良反应。结论三苯双脒治疗钩虫、蛔虫感染者的疗效显著,不良反应率低。更多还原

【Abstract】 Objective To evaluate the efficacy and safety of tribendimidine in the treatment of patients witHⅠntestinal nematodiasis.Methods An open clinical trial was conducted in Tunchang County,Hainan Province.Of the enrolled patients,785 patients had intestinal nematodiasis.Hookworm,roundworm or other helmintHⅠnfections were diagnosed by the improved Kato-Katz method.Children(4-14 years old) were treated with tribendimidine at a single dose of 200 mg,while adults(15-70 years old) treated with tribendimidine at a single dose of 300 mg or 400 mg.The efficacy was evaluated by stool examination 3-4 weeks post treatment.Results The cure rate and effective rate of the patients with hookworm infection were 86.57%(606/700) and 98.86%(692/700),respectively,while in patients with roundworm infection,they were 82.84%(111/134) and 98.51%(132/134),respectively.The cure rate and effective rate in children with hookworm infection were 86.16%(249/289) and 98.62%(285/289),respectively,while they were 81.75%(103/126) and 99.21%(125/126),respectively,in children with roundworm infection.The adverse effects of tribendimidine,such as dizziness,nausea and vomiting,were mild and transient with an adverse effect rate of 2.42%(19/785);no adverse effects were found in children.No apparent impact was seen in routine blood,urine and hepatic and renal function test or ECG examinations.Conclusion Tribendimidine was effective and safe for the treatment of patients infected with hookworm and roundworm.更多还原