【摘要】 目的了解<3岁呼吸道感染住院患儿肺炎链球菌呼吸道携带情况及主要危险因素和肺炎链球菌的耐药情况。方法对苏州儿童医院2006年3月-2007年3月453例呼吸道感染住院患儿进行陪护家长的问卷调查,用深部呼吸道吸痰法采集痰标本进行肺炎链球菌的检测,分析其耐药情况。结果453例呼吸道感染住院患儿肺炎链球菌的检出率为9.3%,与年龄和季节有一定的关联;检出的42株肺炎链球菌对青霉素、红霉素、四环素、克林霉素、氯霉素、复方新诺明的耐药率分别为16.7%、100.0%、95.2%、95.2%、14.3%、73.8%,所有菌株对万古霉素、利福平和氧氟沙星敏感;42株肺炎链球菌对≥3种抗菌药物的耐药率达100.0%。结论苏州地区<3岁呼吸道感染住院患儿呼吸道肺炎链球菌携带率较低,年龄和发病季节是呼吸道感染儿童肺炎链球菌携带的危险因素,肺炎链球菌的耐药现象严重。更多还原

【Abstract】 OBJECTIVE To study the carriage,the risk factors and the antibiotic resistant pattern of Streptococcus pneumoniae isolated from hospitalized children with respiratory infection below 3 years old.METHODS A total of 453 children with respiratory infection hospitalized at Children′s Hospital of Soochow University in Suzhou Jiangsu Province from Mar 2006 to Mar 2007 were enrolled and given deep orotracheal aspiration(OTA) technique to get the sputum.S.pneumoniae strains were tested and analyzed.RESULTS The carriage rate of S.pneumoniae was 9.3% which was related with age and season.The percentage of resistance to penicillin,erythromycin,tetracycline,clindamycin,chloramphenicol and trimethoprim/sulfamethoxazole was 16.7%,100%,95.2%,95.2%,14.3% and 73.8%,respectively.No resistant strains to ceftriaxone,ofloxacin and vancomycin were detected.All S.pneumoniae strains were resistant to multiple drugs.CONCLUSIONS The carriage of S.pneumoniae in respiratory infected children below 3 years old in Suzhou area is relatively low.Age and incidence season are the risk factors.The antibiotic resistance is serious.更多还原