【摘要】 目的探讨利奈唑胺对耐甲氧西林金黄色葡萄球菌(MRSA)反复感染的临床疗效,为临床合理选用抗菌药物提供指导。方法对2008年2月-2009年1月3例使用利奈唑胺治疗MRSA反复感染的危重症患者进行回顾性分析,对利奈唑胺的临床疗效进行观察。结果3例患者均多次检出MRSA,体外药敏试验对糖肽类药物敏感,选用万古霉素或替考拉宁抗感染治疗,疗效欠佳;多次使用利奈唑胺治疗临床疗效确切。结论利奈唑胺治疗MRSA反复感染临床疗效确切,但不能有效清除致病菌。更多还原

【Abstract】 OBJECTIVE To investigate the clinical therapeutic effect of linezolid to repeatedly meticillin-resistant Staphylococcus aureus(MRSA)infection.METHODS We reviewed three severe patients who developed MRSA repeatedly from Feb 2008 through Jan 2009.Linezolid was used to control the infection,and its clinical therapeutic effect was observed.RESULTS MRSA was detected in the three patients repeatedly,and it showed high susceptibility to glycopeptides antibiotics in vitro.But the clinical therapeutic effect of vancomicin and teicoplanin to it was poor.And linezolid′s was sure,though being used repeatedly.CONCLUSIONS The clinical therapeutic effect of linezolid to repeatedly MRSA infection is sure,but the pathogenic bacterium could not be eradicated effectively.更多还原