【摘要】 目的分析2001-2005年血液肿瘤患儿医院感染病原菌特点,为及时诊断、经验性治疗提供参考。方法病原菌标本常规进行分离、培养及鉴定,采用K-B法进行药敏试验,根据NCCLS标准判定结果。结果血液肿瘤患儿发生医院感染以条件致病菌为主,G-菌和真菌常见,G-菌对头孢类等抗菌药物敏感性下降(对常用头孢耐药率约50%),G+菌大多为耐药菌(对青霉素类、红霉素耐药率高达70%～90%)。结论医院感染菌对抗菌药物具有较广耐药性,抗菌药物选择要根据不同时期不同地点的药敏结果进行调整。更多还原

【Abstract】 OBJECTIVE To investigate the pathogenic distribution and drug resistance of nosocomial infection occurred in pediatric patients with hematologic malignancy and therefore provide the information in rational administration of antibiotics to pediatric patients with hematologic malignancy complicated with nosocomial infection.METHODS Flora cultivation and isolation were operated with the routine methods and drug-sensitivity was determined by Kirby-Bauer method.RESULTS Totally 116 strains of pathogenic bacteria were isolated,in which included 78 strains of G-bacteria and 38 strains of G+ bacteria.Fungi were also very common.In this study,both G-and G+ bacteria were resistant to antimicrobial agents tested.CONCLUSIONS The bacterial spectrum and their drug-resistance characteristics in pediatric patients with hematologic malignancy are quite different to that encountered in pediatric patients with other systemic diseases.Most strains present high resistance to antibiotics,so our administration of antibiotics for nosocomial infections should be directed and carry out according to the susceptibility tests in different area and different periods.更多还原