【摘要】 目的了解耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)耐药基因流行病学状况。方法对40株MRCNS进行了mecA、aac(6′)/aph(2″)、aph(3′)-Ⅲ、ermA/B/C、tetM检测。结果40株MRCNS mecA、aac(6′)/aph(2″)、aph(3′)-Ⅲ、ermA/B/C、tetM基因阳性株分别为39、32、15、30、2株,阳性率分别为97.5%、80.0%、37.5%、75.0%、5.0%;其中同时检出mecA基因、aac(6′)/aph(2″)/或aph(3′)-Ⅲ基因、ermA/B/C基因26株(65.0%)。结论65.0%MRCNS已同时携带mecA、aac(6′)/aph(2″)/或aph(3′)-Ⅲ、ermA/B/C基因。更多还原

【Abstract】 OBJECTIVE To study the epidemiology of the drug-resistant genes in meticillin-resistant coagulase negative staphylococcus(MRCNS).METHODS mecA,aac(6′)/aph(2″) and aph(3′)-Ⅲgenes of aminoglycoside-modifying enzyme(AME) and ermA/B/C genes of erythromycin methyltransferase were detected by polymerase chain reaction(PCR) from 40 MRCNS strains.RESULTS Thirty-nine strains carried mecA gene,32 strains with aac(6′)/aph(2″) gene,15 strains with aph(3′)-Ⅲ gene,30 strains with ermA/B/C gene and 2 strains with tetM gene in 40 MRCNS strains.CONCLUSIONS About 65% MRCNS strains carry mecA,aac(6′)/aph(2″),/aph(3′)-Ⅲ and ermA/B/C genes at the same time.更多还原