【摘要】 目的探讨乌司他丁对重度烧伤患者早期重要脏器功能的作用并观察其对白细胞介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平的影响。方法将40例重度烧伤患者随机分为实验组和对照组,每组20例,对照组按常规抗休克、创面处理和营养治疗,实验组在常规抗休克、创面处理和营养治疗的基础上加用乌司他丁,测定两组血标本ALT、AST、CK、BUN、Cr、IL-8及TNF-α浓度。结果患者入院即刻查血ALT、AST、CK、BUN、Cr、IL-8及TNF-α浓度均明显增高,两组差异无统计学意义(P﹥0.05)。用药第3天、第7天实验组血ALT、AST、CK、BUN、Cr、IL-8及TNF-α浓度较对照组明显下降,两组差异有统计学意义(P<0.05)。结论乌司他丁能减轻由细胞炎性因子介导的炎性反应,有效保护重度烧伤患者早期各脏器功能。更多还原

【Abstract】 Objective To explore the effects of ulinastatin on major organ functions at the early stage of severe burn and its effects on the levels of interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α ).Methods Forty severe burn patients were randomly divided into the treatment group(n=20) and the control group(n=20).Patients in control group received routine therapy, while those in treatment group received intravenous dripping of ulinastatin on the basis of routine therapy.Blood samples were taken for the determination of serum alaninetransaminase(ALT), aspartatetransaminase(AST), creatine kinase(CK), blood urea nitrogen(BUN) , creatinine(Cr) , interleukin-8(IL-8) and tumor necrosis factor-α(TNF-α).Results We detected the serum ALT, AST, CK, BUN, Cr, IL-8 and TNF-α levels of admission Patients of the treatment group and control group before treatment,which significantly increased;showing no significant differences between groups(P﹥0.05).After 2 days and 6 days, the serum ALT, AST, CK, BUN, Cr, IL-8 and TNF-αlevel of the treatment group were significantly decreased more than those of the control group.There was obvious difference between results of two groups(P< 0.05).Conclusions Ulinastatin can decrease the injury severity of inflammatory reaction by the cytokines and obviously protect functions of major organ in patients with severe burn injury at the early stage.更多还原