【摘要】 建立了顶空毛细管GC法同时测定泮托拉唑钠原药中甲醇、乙醇、丙酮、二氯甲烷、乙酸乙酯和甲苯6种有机溶剂的残留量。以DMF-水(8∶2)为溶剂,采用DM-1大口径毛细管柱,FID检测器。6种有机溶剂分别在24～1200、40～2000、40～2000、5～240、40～2000、7～356μg/ml范围内线性关系良好,平均回收率为98.6%～100.3%,RSD为1.3%～2.1%;检测限分别为0.3、0.27、0.19、0.19、0.16、0.8μg/ml。更多还原

【Abstract】 A static headspace capillary GC method was established for simultaneous determination of six residual organic solvents in pantoprazole sodium. A DM-1 capillary column was used with DMF-H2O(8∶2) as the solvent and FID was used as detector. The calibration curves of six solvents were linear in the concentration ranges of 24 -1 200,40 -2 000,40 -2 000,5 -240,40 -2 000,and 7 -356 μg/ml,respectively. The average recoveries were 98.6% -100.3% with RSDs of 1.3% -2.1%. Their detection limits were 0.3,0.27,0.19,0.19,0.16,0.8 μg/ml,respectively.更多还原