【摘要】 目的:探讨柴胡四黄汤对重症急性胰腺炎(SAP)血清细胞因子水平的影响。方法:60例SAP病患者随机分为治疗组和对照组(各30例)。治疗组给予柴胡四黄汤口服,1剂/d;对照组30例,给予大柴胡汤口服,1次/d,疗程均为7 d。测定两组患者治疗前后肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)和白细胞介素10(IL-10)水平。且设正常健康组30例。结果:2组IL-10水平均较健康组低。而TNF-α及IL-6较健康组高(P<0.01)。治疗后治疗组TNF-,αIL-6水平与对照组比明显降低(P<0.01),IL-10与对照组比明显增高(P<0.01),治疗组与治疗前对比P<0.01。结论:柴胡四黄汤能显著调节细胞因子水平,促进SAP早期恢复。更多还原

【Abstract】 Objective: To make a study of the effect of Chaihu Shihuang soup on blood serum level TNF,IL-6 and IL-10 of severe acute pancratitis.Method: Sixty SAP cases were divided at random into treatment group and control group(30 cases each).The treatment group were given chai-hu-shi-huang-soup once a day;the control group were given Dachaihu soup once daily,with both treatment period for 7 days.The tumor necrosis factor-α(TNF-α),interleukin level 6(IL-6) and 10(IL-10 of both groups were determined before and after the treatment.We also had 30 healthy cases.Result: IL-10 level in both groups was lower than healthy group while TNF-α and IL-6 were higher than healthy group(P<0.01).After treatment,the treatment group’s TNF-α,IL-6 level were comparatively lower than that in the control group(P<0.01),and IL-10 level were clearly higher than that of the control group(P<0.01),comparison of the treatment group before treatment(P<0.01).Conclusion: Chaihu Shihuang soup can significantly regulate cytokine and improve early recovery of SAP.更多还原