【摘要】 骨质疏松症主要表现在骨BMD减少,骨质量(骨微结构,骨的转换,骨矿化,骨微损伤累积)降低,诱导骨强度下降,微骨折增加。在临床上,系统性骨质疏松症的典型表现是骨质疏松性疼痛和骨折,而最常见的骨质疏松性骨折部位是:髋部,腰椎和腕部。骨质疏松症可预防,如果早期诊断,可得到治疗。目前有两大类药物可治疗和预防骨质疏松症。①抗骨代谢类药物;②促骨合成药。近年来,大量的基础、临床研究表明vitaminD及其类似物不仅通过抑制骨吸收,而且有促进骨合成作用来防治骨质疏松症,笔者就骨质疏松症的药物研究进展作一综述,为更好的预防和治疗骨质疏松症具有很好的指导意义。更多还原

【Abstract】 Osteoporosis is a systemic skeletal disease characterized by low bone mass,weak of bone strength and deterioration of bone microarchitecture,with a consequent increase in bone fragility and susceptibility to fracture,decreasing bone strength predispose to an increased risk of fracture.The clinical manifestation of the systemic disease of osteoporosis is fracture,and the three vulnerable principal sites of osteoporotic fractures-are the hip,vertebrae,and wrist.Osteoporosis can be prevented,and if diagnosed and treated early.Generally,two kinds of drugs for prevention or treatment of osteoporosis are in the market:(1)Anti-catabolic agents(Inhibitors of bone resorption);(2)Anabolic agents(Stimulation of bone formation).Now,more and more basic and clinical studies have shown that Vit D and its analogs had an anabolic and anti-catabolic effect on bone.So we reviewed the anti-osteoporosis medications to understand better how to use the current medicine to prevent and treat osteoporosis patients.更多还原