【摘要】 目的:研究可溶性药物美司钠缓释微球的最佳制备工艺及体外释药,比较O/W溶剂挥发法与W/O/W复乳溶剂挥发法的优缺点。方法:采用乳化-溶剂挥发法制备美司钠聚乳酸微球。由紫外分析法测定微球的药物含量及体外释药量,正交实验确定2种方法的最佳配比。结果:聚乳酸微球具有很好的控释能力。采用W/O/W复乳溶剂挥发法比O/W溶剂挥发法制备的缓释微球在包埋率、载药量和药物释放性能上更好,而O/W法要更简单、经济。找出可溶性药物微球制备工艺最佳配比。更多还原

【Abstract】 OBJECTIVE To optimize the preparation process and study in vitro release of mesna polylactic acid (PVA) microspheres,and to compare the results of W/O emulsion-solvent evaporation and W/O/W emulsion-solvent evaporation.METHODS Polylactic acid microspheres were preparedby emulsion-solvent evaporation. Content and amounts of accumulative release in vitro were analyzed using ultraviolet spectrometry. Preparation process was optimize by an orthogonal test.RESULTS The controlled-release effect of polylactic acid microspheres was good. Micropheres of prepared by the W/O/W method were better on the incorporation rate,the loading of drug and the drug release performance. The O/W method to be more simple. The optimum preparation process for soluble drug microspheres has been established.更多还原