【摘要】 目的:观察和评价中药杀胚方剂对甲氨蝶呤(MTX)联合米非司酮保守治疗未破裂型输卵管妊娠的辅助作用。方法:将118例未破裂型输卵管妊娠病例分为A、B2组,A组使用MTX+米非司酮+中药联合治疗;B组使用MTX+米非司酮治疗,定期监测血β-HCG及附件区包块大小变化,同时记录不良反应发生情况。结果:总治愈率A组明显高于B组(P<0.05)。单疗程有效率A组高于B组但差异无显著性(P>0.05)。治疗后包块缩小速度(P<0.01)、血β-HCG转阴时间(P<0.05)和临床痊愈时间(P<0.01)A组均较B组明显缩短。胃肠道反应(P<0.01)、肝功能损害(P<0.05)发生率A组显著低于B组。结论:MTX+米非司酮+中药三联药物治疗未破裂型输卵管妊娠具有方法简捷、疗效高、疗程短、不良反应少、保留生育功能等优点,具有推广潜力和价值。更多还原

【Abstract】 OBJECTIVE To observe and evaluate the aidant effect of Chinese herbs on treatment for unrupture tubal pregnancy with methotrexate(MTX) and mifepristone.METHODS 118 cases of unrupture tubal pregnancy were divided into two groups.Group A was treated with intramuscular MTX(50 mg·m-2) and oral mifepristone(25 mg per 12 hours,totally 600 mg),as well as Chinese herbs.Group B was treated with merely MTX and mifepristone of equal dose.RESULTS The curative rate of group A was significantly higher than group B(P<0.05),while the curative rate of single-course was higher in group A but without statistical significance(P>0.05).The speed of reduction of the adnexal mass(P<0.01)、time for serum β-HCG normalization(P<0.05)and clinical recovery time(P<0.01)were shortened in group A.The incidence of side-effect of of gastrointestinal reaction(P<0.01)and hepatic damage(P<0.05)was conspicuously lower in group A.CONCLUSION Conveniency,efficiency,rapidity,safety as well as retention of reproductive capability are advantages of the triplex-therapy for unrupture tubal pregnancy with MTX plus mifepristone and Chineses herbs.更多还原