【摘要】 目的:了解左乙拉西坦治疗中国儿童癫痫的疗效及耐受性。方法:符合纳入标准、排除标准,并治疗超过3个月的癫痫患者75例,其中男53例,女22例;最小年龄1.5月,最大年龄14岁,中位数3岁4个月;部分性发作30例,全面性发作28例,综合征17例;左乙拉西坦使用方法为起始剂量10mg.kg-1,每周添加10mg.kg-1,至最小有效量;每2～4周门诊或电话随访一次,密切观察临床疗效及不良反应,应用3个月以上评价临床疗效。结果:75例患儿中完全控制31例(41.3%),有效30例(40.0%),无效12例(16.0%),加重2例(2.7%)。不同临床类型疗效差异无显著性(P>0.05);未发现不能耐受的不良反应。结论:左乙拉西坦对儿童癫痫不同临床类型均有显著疗效,并且具有良好的安全性。更多还原

【Abstract】 OBJECTIVE To study the efficacy and tolerability of levetiracetam in children with epilepsy.METHODS In this prospective multi-centre,open-label study,seventy-five patients(53 males and 22 females) with epilepsy,aged between 1.5 months and 14 years was treated with levetiracetam for over 3 months.Among these patients,30 children are partial seizure,28 children are primary generalized seizures and 17 children are epilepsy syndrome.The initial dose of 10 mg·kg-1·d-1 was increased with one week steps of 10 mg·kg-1·d-1,up to a minimum effective dose.Record the patients’ frequency of seizure and adverse effects during therapy,evaluation the efficacy and tolerability of levetiracetam after 12 weeks.RESULTS After 12 weeks therapy,30(40.0%) children were effective,31(41.3%) children had been seizure-free,while 12(16.0%) children were ineffective,2(2.7%) children were deteriorate.The efficacy between different seizure groups were no significant differences(P>0.05).CONCLUSION Levetiracetam is effective with good tolerability for children with epilepsy of different clinic types.更多还原