【摘要】 目的:建立比格犬血浆中阿克他利浓度的定量分析方法,测定其在犬体内的血药浓度经时过程,评价缓释片的药动学及相对生物利用度。方法:比格犬6只采用双周期交叉给药的实验方法,测定阿克他利在比格犬血浆内的浓度,用DAS2.0程序拟合药物浓度-时间曲线,求算药物动力学参数。结果:阿克他利缓释片和普通片在比格犬体内过程均符合单室一级吸收模型,剂量校正后与普通片相比,阿克他利缓释片tmax,t1/2延长,Cmax降低,平均生物利用度为(108.9±11.5)%。结论:阿克他利缓释片具有明显的缓释特征,生物利用度与市售普通片等效。更多还原

【Abstract】 OBJECTIVE To establish a method for the pharmacokinetics and bioavailability study of atarit in Beagle dogs.METHODS 6 dogs were divided into two groups by double crossing method in two weeks.The concentrations of atarit in plasma were determined by HPLC,and pharmacokinetics parameters were calculated by DAS2.0 program.RESULTS The pharmacokinetics of atarit tablets and atarit sustained release tablets were fitted to one-compartment modle.After dose revised,the results indicated that tmax and t1/2 of atarit sustained release tablets were longer and the Cmax was lower than atarit tablets.The bioavailability of atarit sustained release tablets relative to atarit tablets was(108.9±11.5)%.CONCLUSION Atarit sustained release tablets have marked sustained release characters.更多还原