【摘要】 目的:研究法罗培南钠连续口服后在中国健康人体的药动学。方法:采用随机设计,10名健康志愿者连续服药5d,每天3次,每次300mg,口服给药,用高效液相色谱法测定血浆和尿液中的药物浓度,计算药动学参数。结果:多次口服法罗培南钠300mg达稳态后,主要药动学参数:消除相半衰期(t1/2z)为(1.01±0.20)h;tmax为(0.9±0.4)h;Cmax为(4.9±1.3)mg.L-1;AUC0-t为(8.7±4.7)mg.h.L-1。结论:法罗培南钠主要药动学参数表明该药较少以原形从肾脏排泄,连续给药未见蓄积,血药浓度在服药后第4天达稳态,较安全。更多还原

【Abstract】 OBJECTIVE To investigate the pharmacokinetics of faropenem in multiple doses to Chinese healthy volunteers.METHODS The drug concentration was detected by HPLC-UV in human plasma and urine.10 volunteers were given with multi-dose faropenem,300 mg each time.The pharmacokinetics parameters were calculated by DAS 1.0.RESULTS The main pharmacokinetics parameters as follow:t1/2 was(1.008±0.205)h;tmaxwas(0.925±0.426)h ;Cmaxwas(4.933±1.323)g·m-1;AUC0-t was(8.732±4.713)g·h·mL-1.The original drug in human urine account for(2.873±3.637)%.CONCLUSION No accumulation in human body was observed after 5 day administrations.The steady state was formed at the 4th day after oral administration.更多还原