【摘要】 目的了解术前测定血清抗甲状腺球蛋白抗体(anti-TgAb)和抗过氧化物酶抗体(anti-TPOAb)在结节性甲状腺疾病中的意义。方法回顾性分析2004年6月至2006年4月期间,术前行血清化学发光免疫分析法测定anti-TgAb和anti-TPOAb,术后经石蜡病理确诊的分化型甲状腺癌(DTC组)63例、腺瘤(TA组)40例、结节性甲状腺肿(NG组)55例、结节型桥本病(HD组)12例的临床资料。比较各组间中位数和超出正常值例数的差异。结果HD组的anti-TgAb和anti-TPOAb测定值均显著高于其他3组(P<0.01)。anti-TgAb和anti-TPOAb大于正常值3,10倍的例数,HD组均显著高于其他3组(P<0.05)。anti-TPOAb抗体大于正常值3倍的例数,DTC组均显著高于NG组(P<0.05);anti-TgAb大于正常值3倍的例数DTC组显著高于TA组和NG组(P<0.05)。二抗体同时增高1,3,10倍的例数HD组均显著高于其他3组(P<0.05)。结论血清anti-TgAb和anti-TPOAb测定值增高最常见于HD,而且测定值越高越有诊断意义。血清anti-TgAb3倍以上增高除HD外,DTC比TA和NG更常见。DTC的anti-TPOAb测定值1、3倍以上增高患者明显多于NG。二者同时增高最大可能是HD。更多还原

【Abstract】 Objective To investigate the significance of detecting serum anti-thyroglobulin (anti-TgAb)and anti-thyroperoxidase antibodies (anti-TPOAb)preoperatively in the diagnosis of thyroid nodules. Methods We detected the serum anti-TgAb and anti-TPOAb preoperatively by chemiluminescense immunoassay in the inpatients of 63 cases of differenciated thyroid carcinoma (DTC),40 cases of thyroid adenoma(TA),55 cases of nodular goiter(NG)and 12 cases of Hashimoto disease(HD). All the patients underwent surgery and postoperative parrafin embedded slide pathological diagnosis from 2004 June to 2006 April. The data was retrospectively analyzed. The median and case number of each group were compared. Results Anti-TgAb and anti-TPOAb values of HD were significantly higher than the other 3 groups respectively (P < 0.01). The HD patients with more than 3 and 10 folds of normal anti-TgAb and anti-TPOAb value was significantly more than the other 3 groups (P < 0.05). The number of DTC patients with more than 3 folds of normal value of the both antibodies was also significantly more than NG group(P < 0.05);the DTC patients with more than 3 folds of normal anti-TgAb value was significantly more than TA group(P < 0.05). In the HD group,the patients whose anti-TgAb and anti-TPOAb value increased 1,3 and 10 folds simultaneously were significantly more than the other 3 groups(P < 0.05). Conclusion Anti-TgAb and anti-TPOAb values elevation the most commonly occurs in HD. The higher the anti-TgAb and anti-TPOAb values are,there is the more significance for diagnosis of HD. 3 folds increased serum anti-TgAb value is more common in HD and DTC than TA and NG. Simultaneous increase of serum anti-TgAb and anti-TPOAb values stronly suggest the diagnosis of HD.更多还原