【摘要】 目的检测诱导细胞死亡的DFF45样效应因子-B(the cell-death-inducing DNA-fragmentation-factor-like effector-B,CIDE-B)在人宫颈癌组织中的表达,探讨其与宫颈癌发生发展的关系。方法采用免疫组化技术检测45例宫颈癌、33例癌前病变和10例正常宫颈组织中CIDE-B的表达。结果CIDE-B蛋白在宫颈癌组织中的表达高于癌前病变及正常宫颈组织(P<0.05),CIDE-B蛋白在癌前病变组织中的表达与正常宫颈组织相比差异有统计学意义(P<0.05)。CIDE-B在宫颈癌组织中的表达与临床分期、病理类型、年龄、组织类型和有无淋巴结转移均无关(P>0.05)。结论CIDE-B蛋白高表达可能与宫颈癌的发生发展有关。更多还原

【Abstract】 Objective To investigate the expression of the cell-death-inducing DNA-fragmentation-factor-like effector-B(CIDE-B)in cervical cancer.Methods Immunohistochemistry was used to examine the expression of CIDE-B in 45 cervical cancers,27 cervical intraepithelial neoplasias(CIN) and 10 normal cervix tissues.Results The CIDE-B expression is higher in cervical cancer than CIN and normal cervix prominently(P < 0.05)and there was statistical significance of CIDE-B expression between CIN and normal cervix(P < 0.05).The CIDE-B expression is not related to age or clinical phase or grade of cellular differentiation or lymph node metastasis(P > 0.05).Conclusion The CIDE-B expression is closely related with the tumorigenesis and development of cervical cancer.更多还原