【摘要】 目的合成3个重要的药物中间体。方法以乳酸乙酯、卤代烷为起始原料,通过烷基化、格氏化、还原、胺解、成盐5步反应得到目标化合物。结果与结论合成目标化合物2-甲氧基-3-戊胺盐酸盐(1)、2-乙氧基-3-戊胺盐酸盐(2)和2-乙氧基-N-甲基-3-戊胺盐酸盐(3),收率分别为18.1%、18.8%、14.3%。目标化合物的结构经MS和1H-NMR谱确证。更多还原

【Abstract】 Aim To synthesize three important medical intermediates.Methods Ethyl lactate and halogenated hydrocarbon as the starting material were transformed to three target compounds via five steps:alkylation,Grignard reaction,reduction,amination and salt-forming.Results and conclusion The total yields are 18.1%,18.8%,14.3% for 2-methoxypentan-3-amine hydrochloride(1),2-ethoxypentan-3-amine hydrochloride(2) and 2-ethoxy-N-methylpentan-3-amine hydrochloride(3) respectively.The synthesized compounds were characterized by 1H-NMR and MS spectral data.更多还原