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随机糖苷化法合成fesogenin的皂苷衍生物
Synthesis of fesogenyl saponins using the random glycosylation strategy
【摘要】 目的为寻找具有生物活性的fesogenin皂苷,设计并合成了一系列fesogenin的皂苷衍生物。方法采用随机糖苷化策略使fesogenin与单糖供体反应,再脱去单糖上的保护基得到目标化合物。结果与结论所合成的23个fesogenin的皂苷衍生物均为新化合物。
【Abstract】 Aim In order to search active fesogenyl saponins,a series of derivatives were designed and synthesized.Methods The fesogenin was reacted with monosaccharide donors using the random glycosylation,then the target compounds were formed through the remove of the protecting groups on the sugar moiety.Results and conclusion Tewenty-three synthesized saponins of fesogenin are all new compounds.
【关键词】 fesogenin皂苷;
化学合成;
随机糖苷化;
【Key words】 fesogenyl saponins; chemical synthesis; random glycosylation;
【Key words】 fesogenyl saponins; chemical synthesis; random glycosylation;
【基金】 国家自然科学基金项目(30772641,20472054)
- 【文献出处】 中国药物化学杂志 ,Chinese Journal of Medicinal Chemistry , 编辑部邮箱 ,2009年02期
- 【分类号】R914
- 【下载频次】194