【摘要】 目的:研究不同浓度人尿激肽原酶治疗急性脑梗死对患者血压的影响。方法:非随机历史对照研究。观察34例低浓度(0.06%)给药者用药第1天的血压变化并与既往47例高浓度(0.3%)给药者相同资料进行比较。比较2组低血压发生情况。结果:低浓度组较高浓度组用药过程中血压下降不明显;2组中合并使用血管紧张素转换酶抑制剂(ACEI)类降压药者均有低血压发生。结论:人尿激肽原酶治疗脑梗死时有一过性轻微降压作用,适当降低给药浓度有利于减少对血压的影响;不同用药浓度下合用ACEI类降压药均可能导致低血压发生。更多还原

【Abstract】 OBJECTIVE:To observe the effects of different concentration of human urinary kallikrein on blood pressure when used for acute cerebral infarction. METHODS: By a non-randomized historical control study,the blood pressure variation of 34 patients on day one after treatment with low concentration (0.06%) of human urinary kallikrein was observed,the occurrence of hypotension in this group was compared with that of another 47 patients (control) treated with high concentration (0.3%) of human urinary kallikrein. RESULTS: The reduction of blood pressure in low concentration group was less obvious than in the high-concentration group. However,hypotension was noted in both groups when angiotensin-converting enzyme inhibitor (ACEI) hypotensive drugs were used concomitantly. CONCLUSION: Human urinary kallikrein for acute cerebral infarction can transiently down-regulate blood pressure slightly,but its effect on blood pressure can be lowered by suitable reduction of its concentration;at any concentration,it can result in hypotension if used in combination with ACEI.更多还原