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正交试验法优选伴抗宁口服液的闪式提取工艺

Optimization of the flash extract technology of Bankangning oral liquid by orthogonal design method

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【作者】 于敏张婧孙忻苏瑾

【Author】 YU Min,ZHANG Jing,SUN Xin,SU Jin(Key Laboratory of Biological Medicine Preparations of Heilongjiang Province,College of Chemistry & Pharmacy,Jiamusi University,Jiamusi 154007,China)

【机构】 佳木斯大学化学与药学院黑龙江省生物药制剂重点实验室

【摘要】 目的优选伴抗宁口服液的闪式提取工艺。方法采用正交试验法,以苯酚-硫酸比色法测定总多糖的含量为评价指标。采用闪式提取法提取中药材。结果伴抗宁口服液的最佳闪式提取工艺条件为药材用12倍量的水浸泡3 h,提取时间为1 m in,提取电压180 V。供试品平均回收率为99.27%(n=5),RSD%为1.37。结论伴抗宁口服液的提取工艺方法经济、简单、稳定,可行质量可控。

【Abstract】 Objective To optimize the flash extract technology of Bankangning oral liquid.Method An orthogonal design was applied.Content of polysaccharide determined by Phenol-sulfuric method was used as the marker of detection.Result The optimum process for flash extract technology of Bankangning oral liquid were as follows: the medicinal materials was soaked for 3 h with 12 folds amount of water and extracted by flash extractor for 1 min at the voltage of 180 V.The average recovery rate of polysaccharide was 99.27% with RSD of 1.37%(n=5).Conclusion The optimum technology of Bankangning oral liquid is simple,cost-effective,stable and efficient with the quality being controllable.

  • 【文献出处】 中国微生态学杂志 ,Chinese Journal of Microecology , 编辑部邮箱 ,2009年07期
  • 【分类号】TQ461
  • 【被引频次】15
  • 【下载频次】169
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