【摘要】 目的探讨异麦芽低聚糖对D-半乳糖致衰老大鼠肠黏膜功能的影响。方法Wistar大鼠随机分为3组:(1)青年对照组,(2)衰老对照组,(3)衰老观察组(衰老+异麦芽低聚糖)。采用D-半乳糖造成衰老模型后,应用异麦芽低聚糖灌胃,检测各组肠道菌群、血清IgG和肠黏膜sIgA。结果D-半乳糖致衰老大鼠肠道菌群失调;灌胃异麦芽低聚糖后,衰老大鼠肠道双歧杆菌增加(P<0.05),肠杆菌和肠球菌数量减少(P<0.05);血清IgG、肠黏膜sIgA含量增加(P<0.05)。结论异麦芽低聚糖可改善衰老机体肠黏膜功能。更多还原

【Abstract】 Objective To explore the effect of isomalto oligosaccharide on the function of intestinal mucous of the D-galactose-induced aging rats.Methods Wistar rats were randomly divided into three groups,young control group,aging model group and Isomalto oligosaccharide treated group.The model of D-galactose-induced aging rat was established;Isomalto oligosaccharide was given by intragastric application for 30 days.The intestinal flora,serum IgG and intestinal mucous sIgA were measured for every group.Results Dysbacteria could be observed in aging rats;After intragastric application with Isomalto oligosaccharide,the number of Bifidobacteria was increased(P<0.05);the number of Bacterium coli and Enterococcus were decreased(P<0.05);the level of serum IgG and intestinal mucous sIgA were increased(P<0.05).Conclusion The function of intestinal mucous in the D-galactose-induced aging rats can be improved by Isomalto oligosaccharide.更多还原