【摘要】 目的:探讨联合测定血清透明质酸(HA)、层黏蛋白(LN)、Ⅲ型前胶原(PCⅢ)及Ⅳ型胶原(Ⅳ-C)对慢性肝炎肝纤维化的诊断意义。方法:采用放射免疫分析法检测143例肝病患者的HA、LN、PCⅢ、Ⅳ-C,并与30例健康体检者对比。结果:各组肝病四项纤维化指标较对照组有明显升高。结论:联合测定HA、LN、PCⅢ及Ⅳ-C对肝纤维化的诊断有较高的临床价值,并适合于动态观察肝病的进展,对肝病的预后有一定的指导意义。更多还原

【Abstract】 Objective:To investigate the significance of combined testing aminoterminal propeptide of hyalurnoic acid(HA) 、laminin(LN) 、precollagen type Ⅲ(PCⅢ) and collagen type Ⅳ(Ⅳ-C) in the chronic hepatitis with hepatic fibrosis.Methods:Serum HA,LN,PCⅢ,Ⅳ-C of 143 patients with hepatic disease were examined by radioimmunoassay and the results were compared with those of 30 healthy people.Results:Four fibrosis indices of liver disease in each group had significantly increased than the control group.Conclusion:Combined testing HA,LN,PCⅢ and Ⅳ-C is helpful for clinical diagnosis of hepatic fibrosis,and suitable for dynamic observation of the progress of hepatic disease.It is guide significance for prognosis of hepatic disease.更多还原