【摘要】 目的:探讨结肠清颗粒对溃疡性结肠炎模型大鼠血清白细胞介素1(IL-1)、细胞黏附因子(ICAM-1)的影响。方法:用家兔结肠加弗氏佐剂复制大鼠溃疡性结肠炎模型,检测模型大鼠血清IL-1、ICAM-1含量。结果:结肠清颗粒能显著增加溃疡性结肠炎模型大鼠血清IL-1及ICAM-1的含量;显著降低溃疡性结肠炎模型大鼠结肠的病理改变,对模型大鼠结肠有显著的修复作用。结论:结肠清颗粒治疗溃疡性结肠炎的作用可能与其升高血清IL-1及I-CAM-1的含量,从而改善免疫功能,减轻炎症损伤有关。更多还原

【Abstract】 Objective: To study the effects of Jiechangqing granule on the Ulcerative Colitis (UC) rats. Methods: To make the Ulcerative Colitis model rats by rabbit colon and Feud’s adjuvant,and detected contents of IL-1 and ICAM-1 in the serum of the rats. Results: To compare with the model groups,the high-and moderate-dosage groups of Jiechangqing could up -regulated the contents of IL -1 and ICAM -1 and relieve the pathology changes significantly. Conclusion: Jiechangqing granule can up-regulated the levels of IL-1 and ICAM-1 contents in the serum of the rats ,which is the foun dation to cure UC.更多还原