【摘要】 目的:检测前列腺癌(PCA)患者血清胰岛素生长因子-Ⅱ(IGF-Ⅱ)的水平变化,探讨其与肿瘤的分级、分期的关系。方法:采用酶联免疫法(ELISA)测定45例前列腺癌(PCA)患者血清IGF-Ⅱ和前列腺特异性抗原(PSA)水平,并以32例良性前列腺增生(BPH)作对照。结果:PCA组血清IGF-Ⅱ(768.75±65.84)ng/ml高于BPH组(P<0.01)。Ⅲ期+Ⅳ期PCA血清IGF-Ⅱ(879.73±58.25)ng/ml高于Ⅰ期+Ⅱ期(P<0.05)。G3～4级患者IGF-Ⅰ水平(785.46±77.29)ng/ml高于G1+G2(P<0.05)。结论:血清IGF-Ⅱ与前列腺癌的临床分期和病理分级有关,其检测对术前前列腺癌恶性程度评价和筛选中晚期前列癌患者有一定意义。更多还原

【Abstract】 Objective:To determine changes of insulin-like growth factor-Ⅱ(IGF-Ⅱ) in serum with prostate cancer,in view to serum IGF-Ⅱcorrelation with clinical stage and pathology grade.Methods: The serum IGF-Ⅱlevel was measured with ELISA in 45 cases of PCA and in 32 BPH as controls.Results: Level of serum IGF-Ⅱ in patients with PCA(768.75 ±65.84) ng/ml was higher than BPH(P<0.01),the serum IGF-Ⅱ level in stage Ⅲ and stage Ⅳ(879.73 ±58.25) ng/ml was high er than stageⅠandⅡ(P<0.05),the serum IGF-Ⅱ level PCA with G3-4(785.46 ±77.29)ng/ml was higher than G1+G2(P<0.05).Conclusion: Level of serum IGF-Ⅱ is correlated with clinical stage and pathology grade,it may be useful to Preoperative evaluation and prognosis.更多还原