【摘要】 目的:探讨山莨菪碱(anisodamine,654-2)对油酸致急性呼吸窘迫综合征(ARDS)的防治作用及其机制。方法:采用耳缘静脉注射油酸(OA),复制家兔ARDS模型。观察山莨菪碱对血浆丙二醛(MDA)、纤维连接蛋白(FN)、乳酸脱氢酶(LDH)、酸性磷酸酶(ACP)及红细胞超氧化物歧化酶(SOD)含量及肺组织匀浆MDA、SOD和肺泡表面活性物质(PS)含量的影响;同时观察肺脏的病理改变。结果:注射OA前、后各30 min分别给予一定量的山莨菪碱可使OA致ARDS组动物血浆和肺匀浆MDA、血浆LDH及ACP含量降低,且可防止红细胞和肺匀浆SOD、血浆FN和肺匀浆PS减少,各项指标与ARDS组比较均有显著性差异(P<0.05,P<0.01);肺组织病理损伤的程度亦明显减轻。结论:山莨菪碱通过其稳膜作用能阻止ARDS时体内脂质过氧化加强这一过程,对ARDS的发生和发展具有一定的防治作用。更多还原

【Abstract】 Aim: To study preventive and therapeutic effect of anisodamine on acute respiratory distress syndrome(ARDS) induced by oleic acid and their mechanism of action.Methods: Model of ARDS was made in rabbits by oleic acid(OA).The effect of anisodamine on the malondialdehyde(MDA),fibronectin(FN),lactate dehydrogenase(LDH) and acid phosphatase(ACP) in plasma,and superoxide dismutase(SOD) in erythrocyte and MDA,SOD and pulmonary surfactant(PS) in lung tissues homogenate and pathological examination of lung were observed.Results: The administration of anisodamine brfore and after 30 minutes of injection OA decreased MDA,LDH and ACP,prevented the reduction of SOD,FN and PS.Compared with ARDS group,there was marked difference between the two,and alleviated lung injury.Conclusion: Anisodamine possesses preventive and therapeutic effects on ARDS by inhibiting lipid peroxidation and stabilizing membranes.更多还原