【摘要】 目的了解HPV-DNA分型检测在ASC-US患者分层处理中的作用。方法对2005年1月至2007年12月在北京大学第一医院妇产科同时行宫颈细胞学筛查以及HPV-DNA分型检测其中宫颈细胞学结果判读为ASC-US的525例患者的结果进行分析和总结。结果525例ASC-US患者中HPV-DNA分型检测高危亚型阳性者353例,占67.24%,其中HPV-DNA16或(和)18亚型阳性者142例,占总数的27.05%,占高危阳性的40.23%。HPV-DNA高危亚型阳性对CINⅡ及以上病变检出的敏感度为88.06%,特异度为35.81%,对CINⅡ及以上者的阴性预测值为95.35%。HPV-DNA16/18亚型阳性对CINⅡ及以上病变检出的敏感度为55.22%,特异度为77.07%。结论HPV-DNA分型检测在ASC-US患者分层处理中有意义,对HPV-DNA分型检测高危阳性患者尤其是16/18亚型阳性的患者需行阴道镜检查。更多还原

【Abstract】 Objective To explore the effect of HPV-DNA genotyping assays in the ASC-US triages.Methods Among the patients who underwent both cervical cancer screening tests and HPV-DNA genotyping assays in our department between January 2005 and December 2007,525 ASC-US cases were reviewed.Results Among the 525 ASC-US patients,353 cases had positive HPV-DNA genotyping assays high risk results(67.24%).142 cases had positive HPV-DNA genotyping assays 16 or/and 18 results(142/525 cases,27.05% vs 142/353 cases,40.23%).The positive HPV-DNA genotyping assays high risk type results had a sensitivity of 88.06 % and a specificity of 35.81% in detecting CINⅡ or more serious.And the positive HPV-DNA genotyping assays 16/18 type results had a sensitivity of 55.22 % and a specificity of 77.07 %.The negative predicative value of negative HPV-DNA genotyping assays results and positive HPV-DNA genotyping assays low risk subtype results is 95.35% for cervical lesion.Conclusions HPV-DNA genotyping assays are significant in the ASC-US triages.We recommend colposcopy for the patients who have positive HPV-DNA genotyping assays high risk type results,especially positive 16/18 subtype results,that can detect 95.33% patients with CINⅡ or more serious.And the patients who have negative HPV-DNA genotyping assays results or positive low risk subtype results need the regular follow-up.更多还原