【摘要】 目的:观察六味地黄丸、知柏地黄丸对运动大鼠心肌和骨骼肌损伤的影响。方法:将32只SD雌性大鼠随机分为安静组、运动组、运动+六味地黄丸组、运动+知柏地黄丸组。各运动组大鼠进行4周递增负荷游泳训练,测定各组大鼠血清CK、LDH活性,心肌和骨骼肌的SOD、T-AOC、MDA含量。结果:运动+六味地黄组大鼠心肌、骨骼肌的SOD、T-AOC明显高于运动组,而MDA和血清CK、LDH活性均显著低于运动组。运动+知柏地黄组血清CK和骨骼肌MDA均显著低于运动组,骨骼肌T-AOC则显著高于运动组。结论:六味地黄丸可明显增强大鼠抗氧化能力,对运动大鼠心肌和骨骼肌有较强的保护作用;知柏地黄丸对抑制运动引起的骨骼肌损伤有一定的作用。更多还原

【Abstract】 Objective:To observe the Liuwei Dihuang Wan′s and zhibai Dihuang Wan′s influences on the damage of cardiac muscle and skeletal muscle of rats. Method:Thirty-two SD female rats were distributed into quiet group、 motion group、motion and Liuwei Dihuang Wan group,motion and zhibai Dihuang Wan group. Each motion group went along with swim of load increasing by steps in 4 weeks. CK,LDH content of serum,the content of SOD,T-AOC,MDA in cardiac muscle and skeletal muscle of all rats were tested. Result:Rats in motion and Liuwei Dihuang Wan treated group have more SOD,T-AOC in cardiac muscle and skeletal muscle and less active of CK,LDH in serum than the motion group. Rats in motion and treated with Zhibai Dihuang Wan group had much less CK in serum,much less MDA and much more T-AOC in skeletal muscle than motion group. Conclusion:Liuwei Dihuang Wan can increase the rat′s anti-oxidation ability obviously and have great ability of protect rats from motional tissue injure. Zhibai Dihuang Wan have some effects on restrain the damage coursed by free radicals which are come with motion,but the effect is not so obviously as Liuwei Dihuang Wan.更多还原