【摘要】 目的:探索步行训练提高脊髓损伤(SCI)后运动功能的脊髓可塑性机制。方法:84只成年雌性Wistar大鼠随机分为假手术组(n=18)、胸髓横断模型组(n=33)、SCI后减重平板步行训练(BWSTT)治疗组(n=33),分别于术后第7天、15天、45天,通过光镜和电镜观察SCI大鼠脊髓腰膨大内前角神经元形态结构的变化。结果:胸髓横断大鼠BWSTT后,腰髓前角神经元超微结构出现代偿性改变。结论:BWSTT后胸髓横断大鼠可通过增强脊髓损伤平面以下腰髓前角神经元的可塑性,促进其后肢运动功能的恢复。更多还原

【Abstract】 Objective:To investigate the spinal cord plasticity mechanism of locomotor training on improving locomotion after transthoracic spinal cord injury(SCI) . Method:Eight-four adult female rats were divided into Sham,SCI and post SCI body-weight-support treadmill training(BWSTT) groups. The morphology of intact lumbar enlargement(caudal to the lesion) was observed under light microscope and electron microscope at the 7th d,15th d and 45th d postoperatively. Result:After BWSTT ultrastructure of neurons in lumbar cord anterior horn of transthoracic SCI rats appeared compensative changes. Conclusion:BWSTT can improve locomotion of transthoracic SCI rats by promoting the neuronal plasticity of lumbar cord anterior horn.更多还原