【摘要】 目的评价单用替米沙坦与替米沙坦联合吲达帕胺缓释片对老年原发性高血压患者的动态血压(ABP)、脉压(PP)、血压晨峰(MBPS)的影响。方法老年原发性高血压患者102例,随机分为替米沙坦组(80 mg/d,n=50)及替米沙坦联合吲达帕胺缓释片组(联合用药组,80 mg/1.5 mg,n=52),治疗前及治疗后12周监测24 h ABP,分别评估白天和夜间收缩压(SBP)、舒张压(DBP)、PP和凌晨5:00-8:00的血压及MBPS。结果治疗12周后,两组24 h的SBP、DBP和PP均较基线血压显著降低(均P<0.01),联合用药组24 h和白天SBP、DBP、PP的降幅均显著大于替米沙坦组(均P<0.05);联合用药组夜间SBP和PP的降低均显著大于替米沙坦组(均P<0.01),但DBP的降幅两组无显著差异(P>0.05);在服药间歇的最后4 h(凌晨5:00-8:00),两组SBP、DBP、PP均显著降低,联合用药组的降低程度显著大于替米沙坦组(P<0.01);联合用药组SBP和DBP的晨峰降幅亦显著大于替米沙坦组(P<0.01),MBPS减少百分比(31%)显著大于替米沙坦组的18%(P<0.01)。结论替米沙坦和替米沙坦联合吲达帕胺缓释片均可显著降低老年原发性高血压患者的动态SBP、DBP、PP、凌晨血压和MBPS,联合治疗显著优于单用替米沙坦,特别是血压晨峰。更多还原

【Abstract】 Objective To evaluate the effects of combined telmisartan with indapamide sustained release(SR) on ambulatory blood pressure(ABP),PP and MBPS in older hypertensive patients using ambulatory blood pressure monitoring(ABPM).Methods One hundred and two older hypertensive patients were randomized divided into telmisartan group(80 mg/d,n=50) or telmisartan/indapamide SR group(combination group,80 mg/1.5 mg,n=52).ABPM was performed at baseline and the end of 12 weeks treatment periods.Results 24 h and daytime SBP/DBP and PP were significant decrease from baseline in both group(P<0.01 respectly);combination treatment produced greater reduction in the SBP/DBP and PP compared with telmisartan monotherapy(P<0.05 respectly);combination treatment decreased SBP and PP more significant than that of telmisartan monotherapy,P<0.01 respectly.Furthermore,combination treatment reduced morning SBP and DBP surge were more pronounced those by telmisartan as well(P<0.01).Conclusion Combination of telmisartan/indapamide SR significantly reduce the 24 h ambulatory SBP,DBP and PP,and attenuated the extent of MBPS in elder hypertensive patients;telmisartan/indapamide SR were more effective than telmisartan alone in reducing morning surge.更多还原