【摘要】 目的探讨蛋白酪氨酸磷酸酶N22(Prote in Tyrosine Phosphatase-22,PTPN22)基因1858C/T多态性与贵州省汉族人群类风湿性关节炎(RA)及系统性红斑狼疮(SLE)的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,分析110例RA患者及98例SLE患者与120例正常对照组的PTPN22基因1858C/T多态性。结果RA组、SLE组及正常对照组的PTPN22 1858C/T基因型均为CC型,1858C等位基因频率均为100%,未发现PTPN22基因1858C/T多态性。结论PTPN22基因1858C/T多态性与贵州省汉族人群RA及SLE无关。更多还原

【Abstract】 Objective To probe the association of 1858C/T gene polymorphisms of protein tyrosine phosphatase-22(PTPN22) with rheumatoid arthitis(RA) and systemic lupus erythematosus(SLE) in Han population in Guizhou province.Methods The 1858C/T gene polymorphism was analyzed with polymerase chain reaction restriction fragment lengh polymorphism(PCR-RFLP) in 110 patients with RA,98 patients with SLE and 120 healthy controls.Results The genotype of PTPN22 1858C/T in RA,SLE and healthy controls were CC type,and the +1858C allele distribution was 100%.PTPN22 1858C/T polymorphism was not found in RA patients,SLE patients and the controls.Conclusion The 1858C/T gene polymorphism of PTPN22 was not associated with RA and SLE in Han population in Guizhou province.更多还原