【摘要】 目的了解北京市散发性戊型肝炎(HEV)的流行病学特征。方法回顾性分析2002年7月-2007年7月首都医科大学附属北京佑安医院就诊的患者17 324例,用酶联免疫吸附试验方法检测血清抗-HEV IgM/IgG的戊型肝炎感染标志物。结果2002-2007年的抗-HEV检测阳性率分别是6.26%,8.83%,11.30%,8.38%,9.36%,各年间比较差异有统计学意义(χ2=56.69,P<0.000);17 324例患者血清抗-HEV共有1 541例阳性(8.94%);抗-HEV阳性患者中男性为1 256例(81.51%),女性285例(18.49%);单纯抗HEV IgM阳性617例(40.04%),单纯抗HEV IgG阳性329例(21.35%),抗-HEV IgM与HEV IgG阳性均为阳性595例(38.61%);戊型肝炎抗体阳性患者中单纯急性戊型肝炎1 067例(69.24%),戊型肝炎病毒重叠感染乙型肝炎患者350例(22.71%),戊型肝炎重叠其他型肝病患者感染124例(8.05%);随着年龄增长抗-HEV阳性率逐渐增加。结论北京市2002-2007年散发性戊型肝炎发病率有波动,并呈明显的年龄特征。更多还原

【Abstract】 Objective To investigate the epidemiological feature of sporadic acute hepatitis E in recent five years in Beijing.Methods Serum samples were collected from 17 234 patients(14 048 mael,3 186 female)with liver disease,and tested for anti-HEV IgM and IgG by ELISA.Results The rates of hepatitis E virus(HEV) infection were significant different between the years(χ2=56.69,P<0.000).The yearly seroprevalence rate of HEV-specific antibody was 6.26%,8.83%,11.3%,8.38%,and 9.36% form July 2002 to July 2007,respectively.Among 1 541 patients with liver disease,8.94% were positive for anti-HEV(81.51% in the male,18.49% in the female).Among all anti-HEV positive patients,617(40.04%)were positive for anti-IgM,329(21.35%) were positive for anti-HEV IgG,and 595(38.61%) were positive both for anti HEV IgM and anti-HEV IgG.The positive rate of anti-HEV was increased with age.In children and the elderly patients more than 70 years old,the rates were decreased.Among all positive anti-HEV patients,69.24%(1 067/1 541) had acute hepatitis E,22.71%(350/1 541) had co-infection of HEV and HBV,8.05%(124/1 541) had other liver diseases.Conclusion The result suggested that the HEV infection was sporadic in Beijing from 2002 to 2007.The infection rates were lower in children and the elderly more than 70 years old.更多还原