【摘要】 目的了解有机磷酸酯和氨基甲酸酯类农药在大鼠和小鼠体内的蓄积毒性效应,建立评价这两类农药在大鼠和小鼠体内的蓄积毒性测定方法。方法采用2种评价方法-大鼠的剂量固定20 d蓄积法和小鼠的剂量递增法同时对这两类杀虫剂的蓄积毒性进行测试。结果所测定的这两类共8种杀虫剂蓄积系数均大于5,在机体内属于轻度蓄积。结论固定剂量法和剂量递增法均可用于大鼠和小鼠的体内蓄积毒性评价。常用的有机磷和氨基甲酸酯类农药蓄积性较弱。更多还原

【Abstract】 Objective To develop a method for evaluating the cumulative toxic effects of these widely used organophosphate and carbamate pesticides exposed to rats and mice.Methods Wistar rats and ICR mice were treated with four kinds of organophosphorus pesticides and four kinds of carbamate pesticides at a fixed dosage during 20 days experiment period or an increased dosage with increase every four days during the same experiment days,respectively.After 20 days consecutive administration,the animal death rates were calculated and the toxicity of the pesticides were evaluated.Results the number of dead animals in each group is less than 50% of the total;the cumulative coefficient K is more than 5(K>5).Conclusion The procedure described in the present study is simple and easy to deal with.Both the organophosphate and carbamate pesticides are weak cumulative toxicity.更多还原