【摘要】 背景与目的:随着我国经济的快速发展,人们的生活水平大幅提高,膳食模式也发生了变化,这可能会增加肠癌发生的危险。本研究分析1970年—2005年期间山东省肠癌患者死亡率的变化趋势,为肠癌的防治提供理论依据。方法:利用1970年—2005年期间的4次全死因调查资料,计算肠癌患者死亡率和世界人口标化死亡率,并利用Joinpoint软件分析肠癌患者死亡率的升降速率及其变化特征。结果:山东省肠癌患者的死亡率由1970年—1974年期间的3.62(标化率4.33)上升到2005年的6.96(标化率5.77),按标化率计算上升了33.26%;其中男性上升了50.75%,女性上升了6.97%。1970年—1974年期间和2005年男女性别比分别为1.1∶1.0和1.4∶1.0。回归分析显示,肠癌死亡率在1970年—1992年期间呈上升趋势,年均增长速率为1.05%(P=0.042);从1922年开始呈稳定缓慢小幅上升趋势;肠癌死亡率随着年龄的增长而升高,从35岁开始,各年龄组患者的肠癌死亡率加速上升;男性高于女性,城市高于农村。结论:山东省肠癌死亡率呈上升趋势,应加强预防肠癌发生的知识宣教。更多还原

【Abstract】 Background and purpose:With the development of economy,people’s living standards have improved greatly in recent years.However,the diet patterns have also changed,which could increase the risk of colorectal cancer.The aim of our study was to analyze the trend of colorectal cancer mortality in Shandong Province from 1970 to 2005 and to explore a prevention strategy.Methods:All causes-related survey data from 1970 to 2005 were collected in Shandong Province.Crude and standardized mortality rates of colorectal cancer were calculated separately.The software of Joinpoint was used to analyze the fluctuation character and the long-term trends of standardized mortality rate of colorectal cancer.Results:The standardized mortality rate of colorectal cancer in Shandong Province was 4.33 and 6.96 in 1970-1974 and in 2005 respectively.It increased by 33.26%,of which male increased by 50.75% and female by 6.97%.The sex ratios of colorectal cancer(male versus female) were 1.1:1.0 and 1.4:1.0,respectively.The mortality rate of colorectal cancer in Shandong Province showed an increasing trend with an APC(annual percent change) of 1.05%(P=0.042) from 1970 to 1992,and increased constantly and slowly from 1992 to 2005.It increased with the increase of age and speeded up from the age of 35.The mortality rate was higher in men than in women,and higher in the city than in the countryside.Conclusion:The mortality rate of colorectal cancer is increasing,therefore health education to prevent colorectal cancer should be strengthened.更多还原